Targeted Degradation of the Epidermal Growth Factor Receptor with Supramolecular PROTAC Polymers

Project Description

Proteolysis targeting chimeras (PROTACs) have the potential to revolutionize therapeutic development as we know it. This is provided that these strategies can overcome the translational challenges of targeted delivery, improved specificity and cellular internalization. The goal of this project is to couple this advanced synthetic biology technique with supramolecular polymers to address these significant hurdles currently facing the field. The success of this project could unlock a vast array of new drug targets, previously thought to be undruggable, while circumventing the reliance on small molecule therapeutics and their associated problems with drug resistance.

Instruments