About the Platform
The NSF BioPACIFIC MIP (DMR-1933487) operates a one of a kind user facility dedicated to creating a nexus for synthetic biology and materials to revolutionize high-performance polymers. Users are uniquely able to elucidate biomaterial structure and function to achieve materials-by-design, construct new bio-derived functional monomers from living organisms, access novel sequence-specific materials (e.g. peptoids), synthesize stimuli-responsive “smart” biomaterials, scale-up biomaterial production, and incorporate state-of-the-art field-theoretic simulation and machine learning algorithms. The bulk of the platform activity is devoted to the design and development of unique automated materials synthesis and characterization capabilities with the realization that these tools address a major gap in the US mid-scale and large-scale instrumentation portfolio available to engineers and scientists in this country. In all cases, this platform is made possible by the unique and collective expertise of the BioPACIFIC MIP faculty and staff. BioPACIFIC MIP facilities are open to all US scientists via a reviewed User Proposal process.
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BioPACIFIC MIP Wiki
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UC Santa Barbara
The UCSB hub of the BioPACIFIC MIP enables users to complete the Design-Build-Test-Learn cycle for novel bio-derived polymers by providing access to advanced simulation tools for flexible, inverse design. Automated synthetic and flow chemistry equipment suites, coupled to a dedicated library of monomers, allows rapid structure-property determination via next-generation X-Ray scattering characterization and high-throughput micro-rheology. Additive manufacturing tools accommodate both user-designed and in-house building blocks to facilitate next-generation materials discovery and advanced constructs.
UC Los Angeles
The UCLA hub of the BioPACIFIC MIP enables users to accelerate the discovery and scale-up production of bio-derived building blocks and biopolymers using a robotic and automated Living Bioreactor system for gene assembly, amplification, transformation, strain growth, and metabolite analysis. A mineable data library of biosynthetic pathways is under development and will be made available to users. Users also have access to the BioPACIFIC MIP’s first of its kind Cryo-EM microcrystal electron diffraction (MicroED) system that provides accelerated 2D and 3D structure determination of small molecules, peptides/peptoids, and semi-crystalline polymers.
Related Videos
BioPACIFIC MIP Automated Chemistry Facility: Robotic Polymer Synthesis
BioPACIFIC MIP microED: Three‐dimensional electron crystallography of microcrystals
BioPACIFIC MIP Living BioFoundry: Automated Gene Assembly & Metabolite Analysis
BioPACIFIC MIP Town Hall January 2022
Summer School 2021 - Synthetic Biology for Chemical Production - Y. Tang
BioPACIFIC MIP Living Biofoundry Install Time-Lapse
Summer School 2021 - Solutions for R&D Automation Developed by Chemists - B. Schmidt
Summer School 2021 - Introduction to Automated Solid Phase Peptide Synthesis - C. Quick
Summer School 2021 - High-Throughput Characterization of Microstructure and Microrheology - M. Valentine and M. Helgeson
Summer School 2021 - Practical Approaches in Electron Diffraction - J. Rodriguez
Summer School 2021 - Multiscale Modeling of Complex Polymeric Materials - S. Shell
BioPACIFIC MIP X-ray Facility Construction
Acknowledging BioPACIFIC MIP Building Community
The BioPACIFIC MIP platform can only thrive through the development of a critically large community of engaged researchers. Communication, contextualization, and acknowledgement of how BioPACIFIC MIP resources enable results helps prospective users understand how they might advance their research by joining the community.
To promote this mission of knowledge sharing and growth, researchers working on approved user projects or in-house research at BioPACIFIC MIP should:
- Mention BioPACIFIC MIP within the main body of publications, in the methods section or where the facilities or procedures are described; example: “SAXS measurements were performed at the BioPACIFIC MIP user facilities at UC Santa Barbara.”
- Include the BioPACIFIC MIP logo and mention the relevant instrumentation when describing experimental methodologies in conference presentations and posters; see the video in the inset for an example.
And must:
- Acknowledge both the BioPACIFIC MIP award number (DMR-1933487) and the BioPACIFIC MIP name in all publications that are generated or resulting from BioPACIFIC MIP in-house research and BioPACIFIC user projects, including through use of the BioPACIFIC MIP funded tools, materials, or data in person or virtually; example: “This work was supported by the BioPACIFIC Materials Innovation Platform of the National Science Foundation under Award No. DMR-1933487.”
- Acknowledge the BioPACIFIC MIP award number (DMR-1933487) and/or BioPACIFIC MIP name in all presentations, websites, press releases, etc. that are generated or resulting from BioPACIFIC MIP support under the Materials Innovation Platforms solicitation (NSF 19-526).
For users accessing the facilities through the recharge/fee mechanism:
- The BioPACIFIC MIP award number (DMR-1933487) must be acknowledged in all publications that are generated or resulting from BioPACIFIC MIP support under the Materials Innovation Platforms solicitation (NSF 19-526), including use of the BioPACIFIC MIP funded tools, materials, or data in person or virtually.
- The BioPACIFIC MIP award number (DMR-1933487) and/or BioPACIFIC MIP name must be acknowledged in all presentations, websites, press releases, etc. that are generated or resulting from BioPACIFIC MIP support under the Materials Innovation Platforms solicitation (NSF 19-526).
