The Symphony X (Gyros Protein Technologies) is a flexible, automated synthesizer that enables the preparation of novel peptoids and other solid-phase synthesis sequence specific materials. It provides a viable route to non-commercial products, branched or cyclic materials. The system also includes the ability to perform in-situ pre-activation, special reagent additions with no waste of precious starting materials, as well as automated and fully customizable cleavage.

Multi-user accessibility is facilitated via 12 fully independent reaction stations, enabling different sequences, scales, and protocols to be run simultaneously. When larger scale is needed, each reaction station can be configured to run two reactions of the same sequence concurrently, effectively doubling the system’s capacity to 24 reactions at a time. Typical scales span 10 mg to 1 g of resin in 10- or 40-mL reaction vessels (RVs) with IR heating up to 90ºC for one RV to accelerate difficult deprotections and couplings. Agitation of each RV is performed by nitrogen bubbling. The Symphony X at BioPACIFIC MIP has also been pre-configured with a number of optimized methods for rapid peptoid synthesis.