A custom-built Solution Mask Liquid Lithography (SMaLL) 3D printing system enables the direct incorporation of new, novel bioderived monomers. SMaLL provides users with a universal 3D printing strategy based on orthogonal material sets, enabling users to precisely tune properties and applications of 3D printed objects with properties ranging from rigid to flexible, stimuli-responsive to cross-linked thermosets and biocompatible in the same object. This 3D printing system consists of a scanner, multiple-wavelength projection source, an automated build stage, and multiple reservoirs for user-defined resins, and is meant to provide users with a versatile and flexible tool that can use in-house dual-resin formulations or user-designed materials.