In-house Research Scope
The in-house research program at the BioPACIFIC MIP focuses on the integrated simulation, fabrication, and property characterization of tactic, sequence-controlled, or stimuli-responsive polymers synthesized from a library of chiral, regioselective, and functional bio-sourced monomers.
Synthetic biology in the automated and high-throughput Living Bioreactor Platform (focus at UCLA) produces monomers with stereospecific functional groups from yeast, fungi and bacteria that feed into an Materials Genome Initiative (MGI) based loop of hierarchical computation, automated polymerization and flow chemistry (focus at UCSB). Advanced characterization equipment suites (focus at both UCLA and UCSB) are used to study polymers with high thermal stability, chirality, water solubility, biological activity, as well as stimuli-responsive polymers prepared using automated synthesis facilities (focus at UCSB).
The MGI loop integrates state-of-the-art simulation tools in order to predict the properties of synthesized materials and systematically explore the design landscape of new chiral, regioselective, and functional bio-sourced monomers. Simulation is tightly integrated with structure-property relationship determination to guide molecular-level engineering and chemical formulation toward specific materials targets. A key goal at BioPACIFIC is to provide an understanding of how bio-based materials assemble and carry out function.