The Prelude X system (Gyros Protein Technologies) enables users to synthesize novel peptoids and other solid-phase synthesized sequence specific materials not available for commercial purchase.

This peptoid synthesizer supports various peptidomimetic chemistries and facilitates multi-user accessibility via 6 simultaneous reaction stations with real-time UV monitoring, heating, and vortex mixing on a scale of 10 mg to 2 g of resin per reaction vessel in 10- or 40-mL capacities.

Agitation of the reaction is performed by nitrogen bubbling, oscillation mixing, or a combination of these. The system supports Fmoc, t-Boc, peptoid, and PNA chemistries.

The system is capable of heating all RVs to 90 ºC using induction heating while oscillation mixing the reactor. Elevated temperature can raise reaction rates, accelerating difficult deprotections and couplings that would otherwise cause deletion sequences. Heating can improve the purity of hydrophobic and aggregated sequences.